Christophe Auwer Den, Christophe Di Giorgio, Christoph Hennig, Florian Lahrouch, Laurane Léost, Anne Van Der Meeren
New paradigms in nuclear human decorporation using macromolecular systemsLire ce document Page de ce document
Actinides elements (that are all radioactive) are the subject of special attention considering the important amount that has been produced for military and civil applications. They often present a dual toxicity: chemical and radiotoxicological from α and β decay. In case of dissemination during an accidental nuclear event, the consequences of contamination can initiate the vital process. Ingestion, inhalation and then retention in the target organs will occur. Currently, the golden standard of decorporation is DTPA (diethylenetriaminepentaacetic acid) injected intravenously. It presents a strong complexing constant for some actinides but poor chemical specificity and it is only valid for removing actinides from blood, immediately after contamination. Objectives are to explore the design of biocompatible nano-particles or macromolecules able to release the decorporation agent directly into the target organ. This should constitute a new class of decorporation agents.
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Christophe Auwer Den, Christophe Di Giorgio, Christoph Hennig, Florian Lahrouch, Laurane Léost, Anne Van Der Meeren, " New paradigms in nuclear human decorporation using macromolecular systems", paru dans "Proceedings of the Complex Systems Academy of Excellence ", Proceedings, URL : https://hal.archives-ouvertes.fr/hal-02006706